Monday, 17th February 46th Lorne Genome Conference 2025
Session 4 - Chromatin and Disease
9:00AM - 10:45AM
Monday, 17th February
Heritage Ballroom
Chairs: Qi Zhang & Nir Eynon
- Unlocking the potential of brain organoids for understanding and treating neurodevelopmental disorders. - Silvia Velasco
- Naïve pluripotent stem cell specification by GABPA and PRC2 - Yi Zhang
- Exploring the genome of immune memory in four dimensions - Timothy Johanson
- Mechanisms of SMCHD1-induced gene silencing at the human 15q11.2-13 locus. - Anna LeFevre
Morning Tea
10:45AM - 11:15AM
Monday, 17th February
Convention Centre
Concurrent Session 5A - Computational Biology and Bioinformatics
11:15AM - 1:00PM
Monday, 17th February
Heritage Ballroom
Chairs: Alistair Forrest & Maina Bitar
- Igniting full-length isoform and mutation analysis of single-cell RNA-seq data with FLAMES - Changqing Wang
- Cell type co-localization and cell type-specific microenvironment analysis for spatial transcriptomics data - Mengbo Li
- Unlocking the hidden world of RNA isoforms in single cells using long-read sequencing - Sefi D.J Prawer
- The use of long-read sequencing to improve diagnosis of rare inherited disease - Meutia Kumaheri
- Combined long and short-read single cell RNA-seq to investigate clonal response to treatment in Acute Myeloid Leukaemia - Nadia Davidson
- NucleoScope - base-pair resolution of nucleosome positions, genome-wide - Michael O'Dea
- Characterising the regulatory effects of archaic hominin introgression in Island Southeast Asia - Maddy Comerford
Concurrent Session 5B - Genome in Disease
11:15AM - 1:00PM
Monday, 17th February
Heritage Room
Chairs: Scott Cohen & Natasha Jansz
Sponsored by:
- Disease mechanisms resolved by transactivation of silent genes - Lachlan A Jolly
- Mapping the gene targets of hundreds of non-coding autoimmune risk loci. - Viacheslav A Kriachkov
- Transcriptomic profiling of adipose eosinophils reveals important role in angiogenesis - Annalise M Psaila
- Targeting epigenetic plasticity in small cell lung cancer to enhance anti-tumour immunity - Chelisa Cardinez
- Duplication of 14q32.13 implicates a chimeric CLMN::SYNE3 RNA transcript in cerebellar ataxia - Mark A Corbett
- Epigenetic reprogramming of tumor associated macrophages – targeting the BAF nucleosome remodeling complex - Helen M McRae
- RNA Polymerase I inhibition as a therapeutic strategy for treating H3.3 and ATRX mutated gliomas. - Andrew Garvie
Lunch
1:00PM - 2:00PM
Monday, 17th February
Convention Centre
Free Time / Afternoon Activities
1:00PM - 4:00PM
Monday, 17th February
Afternoon Tea
4:00PM - 4:30PM
Monday, 17th February
Convention Centre
Session 6 - Evolution and Model Organisms
4:30PM - 6:30PM
Monday, 17th February
Heritage Ballroom
Chairs: Frank Grutzner & Marnie Blewitt
- Epigenetic regulation of seed development and plant speciation - Claudia Köhler
- Dating West Antarctic ice sheet collapse using genomic data - Jan Strugnell
- Genomic insights on the rapid radiation and climate adaptation of birds - Guojie Zhang
- Unlocking the seed germination: insights into gene regulation and cell function during Arabidopsis seed-to-seedling transition - Lim Chee Liew
Poster Session 2
8:00PM - 10:00PM
Monday, 17th February
Convention Centre
- Leveraging Population-Specific Selective Pressures to Illuminate Function and Disease - Aaron S Kovacs
- Harnessing CRISPR activation to upregulate TTN as a potential treatment for titinopathies - Anthea Lee
- Detection and characterization of the RNA modification m6A in the human malaria parasite Plasmodium falciparum - Joshua M Levendis
- Transcriptomic changes in adipose tissue-resident eosinophils of mice fed with a high fat diet - Tsz Ho Li
- Oncogenic super-enhancer-mediated gene gating of MYC: novel insights for targeted tumor therapy - Jia Pei Lim
- Targeting POLR2J4 improves the efficacy of PARP inhibitors in triple-negative breast cancer - Xue Lu
- DNA methylation synergy between skeletal and cardiac muscles in ageing - Anna Lysenko
- Φ-Space ST: a platform-agnostic computational method for identifying cell states in spatial transcriptomics studies - Jiadong Mao
- Identification of Molecular Drivers of Neuroblastoma - Sepideh Mehrpour Layeghi
- SET-9 and SET-26 impact transgenerational epigenetic inheritance and germline mortality through their PHD finger and SET domains - Dhruv Monteiro
- DMRT3 involved in sex development via regulating ESR1 expression - Shirin Moradi Fard
- CRISPR-based Screen in Cerebral Organoids Identifies Genes Required for Neurodevelopment - Cesar L Moreno
- Modelling BRPF1 associated neurodevelopmental disorders - Sophie TB Morgan
- Investigating the effects of missense variants of Histone H4 - Nihar Girish Naik
- Exploring the role of miRNAs and their target transcription factors in the development of Neuroblastoma. - Fakhira H Nazki
- Genome-wide association studies of protein phosphorylation levels reveal cellular signalling events linked to disease risk - Elise J Needham
- Effector domains impact genome localisation within the KLF transcription factor family - Vala Nejad Safari
- A high-resolution meiotic crossover map from single-nucleus ATAC-seq reveals insights into the recombination landscape in mammalian sperm - Stevan Novakovic
- The role of TLR4 polymorphisms in gastric carcinogenesis - Ezekiel Otaegui-Campos
- MacroH2A in Genome Organization and Transcriptional Regulation - Arnold Ou
- SCAF4 regulates expression of lengthy CDK12 and CDK13 responsive genes - Oliver Ozaydin
- Decoding transcriptome stress signals from sleep deprivation to predict performance in high-pressure work environments using saliva - Muthukuttige Madusha Nuwanthi Perera
- Transcriptional dynamics and isoform changes in glioblastoma cells during transition from quiescence - Javier Perez Burillo
- Integrative Analysis of Gut Microbiome and Multimodal Stress Responses: Unveiling the Interplay Between Biological, Cognitive, and Physical Factors for Early Stress Detection. - Virginie Dr PERLO
- A Novel Multi-Modal Tool for Isolating and Studying Rare Disease-Causing Clones at Unprecedented Levels - Kelsy Ms Prest
- What has closely related species taught us about the zebrafish (Danio rerio) - Stanislava Wolf Profant
- Modelling DNA demethylation during human B cell maturation - Annelise Quig
- Multi-point targeting of RNA polymerase II transcription cycles and epigenetic networks to investigate their coordinated control of gene-expression - Shenali A. Ranasinghe
- The long and short of it: how nanopore sequencing reveals structural variants in the most mutated of cancers, cutaneous squamous cell carcinoma - Jessica Conley
- nf-core/multiplesequencealign: a framework for the systematic comparison of alternative modelling tools - Leon Rauschning
- Pathogenic biallelic variants in VPS52 encoding an intracellular trafficking protein cause impaired brain development - Sankalita Ray Das
- Gli1+ Chondroprogenitors Drive Long-bone Catch-Up Growth. A GLImmer of Hope for Skeletal Growth Disorders? - Ehsan Razmara
- Long-read single-cell RNA sequencing of endometrial organoids derived from fertile and infertile women uncovers dysregulation of endometrial receptivity - Michaela Sacco
- Development of an Inducible and Reversible CRISPR Screening System to Uncover Regulators of Immune Evasion in Cancer - Maede Salehi
- realfreq: real-time base modification analysis for nanopore sequencing - Suneth Samarasinghe
- Powerful read processing with Matchbox - Jakob Schuster
- Investigating the DNA binding ability of immune-specific chromatin reader Speckled Protein 140 - Cindy Shen
- Role of the Y-chromosome in ethnic disparities and prostate cancer presentation - Pamela XY Soh
- Three-dimensional genome architectural changes highlight region-specific vulnerability and resilience to ageing - Quinn Stacpoole
- Characterising the diversity of T cell receptor repertoires across Indonesian populations - Pongsakorn Sukonthamarn
- Nucleosome eviction at tet/tdg-targeted enhancers occurs independently of the removal of the chromatin mark oxidized-methylcytosine - Marion Turpin
- Leveraging population genetics and cellular transcriptomics to identify novel drug targets in Crohn's disease - Rika Tyebally
- Identification of ethnic diversity in the landscape of mutated lncRNAs in prostate cancer - Korawich Uthayopas
- Dietary methyl donors: exploring supplementation as a treatment for the DNA methylation disorder Tatton-Brown-Rahman syndrome - Hannah K Vanyai
- Mapping non-coding gene regulatory activity in human immunodeficiencies with single-cell transcriptomics - Davide Vespasiani
- The role of Tyro3 in ovarian development - Brittany Vining
- Feeling the heat: development of a high-throughput CRISPR screening strategy to identify factors mediating cytosolic Ca2+ flux - Matthew A Waller
- IsoVis: a website for visualizing and analyzing alternative RNA isoforms - Ching Yin Wan
- CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair - Lu Wang
- Gender-affirming hormone therapy and its impact on the transcriptomic landscape of skeletal muscle - Sisi Wang
- Resolving effects of ASD-associated variants in ciliary gene networks - Michelle Watts
- Comparing megakarocyte development in vivo versus in vitro through single cell and flow cytometry analysis - AnneMarie Welch
- The gene regulatory function of the immune-specific chromatin reader SP140 in human B cells - Gabrielle R White
- Streamlining remote nanopore data access with slow5curl - Bonson Wong
- Menin inhibition as a novel epigenetic therapy for EZH2-driven diffuse large B-cell lymphoma - Rachel M Woodhouse
- A precision approach reveals a monogenic and multifactorial basis of ME/CFS - elizabeth A worthey
- Resolving macrosatellite genetics and epigenetics in FSHD - Lucinda Xiao
- stPipe: A flexible R/Bioconductor pipeline for processing and benchmarking sequencing-based spatial transcriptomics data - Yang Xu
- Benchmarking long-read RNA-sequencing technologies with LongBench2: a cross-platform reference dataset profiling cancer cell lines with bulk and single-cell approaches - Yupei You
- Uncovering the role of ferlins in muscle disease and regeneration: insights from zebrafish models - Safoura Zardadi
- An optimized protocol for quality control of gene therapy vectors using nanopore direct RNA sequencing - Kathleen Zeglinski
- Investigating the molecular mechanisms of histone arginine methylation during virus-specific CD8+ T cell differentiation - Zhongming Zhang
- Evaluating variant pathogenicity prediction tools to establish African inclusive guidelines for germline genetic testing - Kangping Zhou
- A whole-genome CRISPR knockout screen identifies conserved host targets for sea nettle jellyfish cytotoxicity - Christopher E Denes
- Molecular profiling of Tasmanian Devil facial tumour vulnerabilities - Jasmine Kaur