Changes in gene regulation are thought to have been critical to primate evolution. However the role of RNA modification in the evolution of the human brain is poorly understood. N6-methyladenosine (m6A) is a highly abundant chemical RNA modification that regulates many aspects of RNA metabolism. Recent technological developments have enabled m6A sites to be mapped across the transcriptome in human and mouse, yet the modification remains unprofiled in the non-human primate brain. This work leveraged a newly developed sequencing approach - Oxford Nanopore Direct RNA Sequencing (DRS), to profile the m6A epitranscriptome with isoform-level resolution across the dorsal frontal cortex, hippocampus, cerebellum and caudate nucleus in the common marmoset. Over 157,000 m6A sites were identified at single-nucleotide resolution across almost 30,000 RNA isoforms. Regional differences in the overall level of m6A methylation were uncovered across the primate brain, with the cerebellum showing a markedly elevated level of modification. Further comparison with human human brain revealed extensive conservation of region- and gene-level modification patterns, including a set of conserved hypermodified genes enriched in neuron and synapse-related GO terms, and a subset of human-specific modified genes. This project provides unique evolutionary insight into the regulation and function of m6A in the primate brain, and has generated an invaluable dataset for future epitransciptomic research.